Assessment of antiretroviral drugs in vegetables: Evaluation of microwave?assisted extraction performance with and without solid?phase extraction cleanup

This study presents unique data on concentrations of antiretroviral drugs, (abacavir, nevirapine, and efavirenz) in the root, leaf, fruit vegetables. The microwave-assisted extraction, solid-phase liquid chromatography coupled with photodiode array detection were applied to assess drugs vegetable samples. analytical method showed high precision linearity (R2) greater than 0.99, acceptable, accuracy recoveries ranging from 85 103% for extraction 87% 104% extraction. limit quantification ranged 0.020 0.032 ?g/kg 0.068 0.109 0.019 0.066 ?g/L 0.065 0.22 respectively repeatability methods as relative standard deviation was a less 6%. concentration range obtained samples is not detected–1.48 ± 0.5 abacavir, detected–27.9 1.2 detected–13.14 0.1 efavirenz. cleanup resulted low compared without which could be due its limits making it sensitive. However, difference significant. Root vegetables (beetroot) exhibited while nevirapine found have dominant compound.